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A New Hypothesis for the Precursor of Aflatoxin Biosynthesis by Aspergillus flavus
Mayura, K. and Basappa, S. C. and Sreenivasamurthy, V. (1985) A New Hypothesis for the Precursor of Aflatoxin Biosynthesis by Aspergillus flavus. Journal of Food Science and Technology, 22 (2). pp. 130-133. ISSN 0022-1155
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Journal of Food Science and Technology, India, Volume-22(2 (1985) 130-133.pdf - Published Version Restricted to Registered users only Download (172kB) |
Abstract
A comparative study between toxigenic and non-toxigenic, strains of A. flavus was made to elucidate the precursor specificity in aflatoxln biosynthesis using carbohydrate and rat substrates. It was found that non-toxigenic strain- of -A.flavus produced more ethanol than the toxigenic strain and more so under tbe Influence of rice bran oil. This gave a due that aldehyde may be a precursor in aflatoxin biosynthesis rather than acetate. Arselite, an inhibitor of lipoic dehydrogenase increased alcohol accumulation but decreased aflatoxin accumulation without affecting the mycelial growth. But when ethanol is supplemented to the arsenite system, the aflatoxin accumulation was equal to control indicating the diversion or aldehyde to aflatoxin synthesis. This perhaps takes place by feedback inhibition of the conversion of aldehyde to ethanol by the added ethanol. The aflatoxin biosynthesis in resting cells was not affected when alloxan, a specific inhibitor or coenzyme A, was added. This suggests that CoA required in rat synthesis Is not perhaps directly involved In aflatoxin biosynthesis. These data strengthen the hypothesis that it may be the aldehyde mediated by some condensing enzymes which is the bask unit for aflatoxln biosynthesis
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aflatoxln biosynthesis, carbohydrate, rat substrates, aldehyde mediated |
| Subjects: | 500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 04 Biosynthesis |
| Divisions: | Food Microbiology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 22 Jun 2016 10:44 |
| Last Modified: | 22 Jun 2016 10:44 |
| URI: | http://ir.cftri.res.in/id/eprint/12234 |
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