Dietary n-3 but not n-6 fatty acids modulate anthropometry and fertility indices in high-fat diet fed rats: a two-generation study.

Breetha, R. and Mehrdad, Zarei and Pooja, Acharya and Ramaprasad, T. R. (2021) Dietary n-3 but not n-6 fatty acids modulate anthropometry and fertility indices in high-fat diet fed rats: a two-generation study. Journal of Food Science and Technology, 58 (1). pp. 349-355. ISSN 0022-1155

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Abstract

The present study assessed the modulatory potentials of dietary n-3 [a-linolenic acid (ALA, 18:3n-3, eicosapentaenoic acid (EPA, 20:5n-3 ? docosahexaenoic acid (DHA) 22:6n-3), and n-6 fatty acid (LA, 18:2n-6)] on anthropometric parameters and fertility indices in high-fatfed rats. Weanling female Wistar rats were fed with control diet (7% lard), high-fat diet (35% lard, HFL), high-fat with fish oil (21% fish oil ? 14% lard, HFF), high-fat with canola oil (21% canola oil ? 14% lard, HFC) and high-fat with sunflower oil (21% sunflower oil ? 14% lard, HFS) for 2 months, mated and continued on their diets during pregnancy. At gestation day 18–20, the intra-uterine environment was examined in representative rats, and the rest were allowed for delivering pups. The pups after lactation were subjected to mating and feeding trials as above. Growth parameters (body weight, body length (BL), abdominal circumference (AC), thoracic circumference (TC), and Lee index and fertility parameters (litter size and sex ratio) were studied. Feeding HFL diet increased BL (16%), AC (33%) and TC (21%) compared to control (p\0.05). Adipose tissue accumulation was 11% higher in the HFL group compared to control and was lowered with n-3 fatty acid incorporation in the diet. HFL group exhibited a lower percentage of fertility, pregnancy, and delivery indices. Litter size was decreased by 20%, and litter weight was increased by 23% in HFL group compared to control with more male pups. Our study indicated that n-3 to a larger extent than n-6 fatty acids modulated high-fat induced changes in the anthropometric parameters and fertility indices.

Item Type:	Article
Uncontrolled Keywords:	Adipose lipids Dyslipidemia Growth parameters Fatty acids Neonatal parameters
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 11 Lipid Biochemistry
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	04 Dec 2020 06:43
Last Modified:	08 Feb 2021 11:04
URI:	http://ir.cftri.res.in/id/eprint/14696

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