Unraveling the regulatory landscape of Parkinson disease: A molecular symphony of miRNAs, transcription factors, and high-risk genes

Farhan, Zameer and Pratheek, Jain and Kounaina, Jain and Pramod Kumar, P. and Harish Prashanth, K. V. and Vidya, Niranjan and Ravish, H. (2024) Unraveling the regulatory landscape of Parkinson disease: A molecular symphony of miRNAs, transcription factors, and high-risk genes. Neuroscience Letters, 832. pp. 1-7.

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Abstract

MicroRNAs (miRNAs) have emerged as critical regulators of post-transcriptional gene expression, impacting various biological processes (development, differentiation, and progression). In medicine, miRNAs are promising diagnostic biomarkers for neurodegenerative diseases, including Parkinson’s disease (PD). The current study aims at exploring the role of miRNAs and transcription factors (TFs) in regulating genes-associated with PD. Deploying bioinformatics tools, the study identifies specific miRNAs and TFs involved in PD and their potential connections to the organ-disease junction. Notably, certain miRNAs are found to be highly expressed in brain, than compared to blood. Furthermore, the study explores the expression patterns of PD-related genes in different regions of the brain and attempts to construct complex network of interactions contributing to PD pathogenesis. Additionally, the regulatory relationship of two miRNAs namely hsa-miR-375-3p and hsa-miR-423-3p with TFs are well examined. Overall, the study provides a comprehensive moon-shot view of the molecular aspects of PD and their potential therapeutic targets which could be further used as diagnostic biomarkers in early detection, drug design and development attributing towards precision medicine.

Item Type:	Article
Uncontrolled Keywords:	Epigenetics, miRNA, ChIP-seq, Network Pharmacology, Personalized medicine, In-silico Biology
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology
Divisions:	Dept. of Biochemistry
Depositing User:	Somashekar K S
Date Deposited:	05 Mar 2025 10:33
Last Modified:	05 Mar 2025 10:33
URI:	http://ir.cftri.res.in/id/eprint/19183

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