Multimodal magnetic nano-carriers for cancer treatment: Challenges and advancements

Aadinath, W. and Triroopa, Ghosh and Anandharamakrishnan, C. (2016) Multimodal magnetic nano-carriers for cancer treatment: Challenges and advancements. Journal of Magnetism and Magnetic Materials, 401. pp. 1159-1172.

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Abstract

Iron oxide nanoparticles (IONPs) have been a propitious topic for cancer treatment in recent years be- cause of its multifunctional theranostic applications under magnetic field. Two such widely used ap- plications in cancer biology are gradient magnetic field guided targeting and alternative magnetic field (AMF) induced local hyperthermia. Gradient magnetic field guided targeting is a mode of active targeting of therapeutics conjugated with iron oxide nanoparticles. These particles also dissipate heat in presence of AMF which causes thermal injury to the cells of interest, for example tumour cells and subsequent death. Clinical trials divulge the feasibility of such magnetic nano-carrier as a promising candidate in cancer biology. However, these techniques need further investigations to curtail certain limitations manifested. Recent progresses in response have shrunken the barricade to certain extent. In this context, principles, challenges associated with these applications and recent efforts made in response will be discussed.

Item Type:	Article
Uncontrolled Keywords:	Theranostic, Hyperthermia, Cytotherapy, Cancer biology
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology
Divisions:	Food Engineering
Depositing User:	Somashekar K S
Date Deposited:	10 Mar 2025 09:17
Last Modified:	10 Mar 2025 09:17
URI:	http://ir.cftri.res.in/id/eprint/19252

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