A CRISPR-Cas9-Based Therapeutics in Oxidative Stress-Induced Cancer

Nivya, Vijayan and Venkatiesh, V. P. and Vani, Vijay and Anbarasu, Kannan and Baskaran, Vallikannan and Madan Kumar, Perumal (2022) A CRISPR-Cas9-Based Therapeutics in Oxidative Stress-Induced Cancer. In: Handbook of Oxidative Stress in Cancer: Therapeutic Aspects. Springer, Singapore, pp. 1-18. ISBN 978-981-16-1247-3

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Abstract

Oxidative stress is closely related to all aspects of cancer and majorly implicated in several cancer types such as breast, colon, lung, kidney, liver, etc. The elevated levels of reactive oxygen species cause oxidative stress which further lead to cancer progression. Reactive oxygen species are extremely reactive molecules which play a pivotal role in the maintenance of cell’s redox state. Increased reactive oxygen species lead to genetic instability and alteration of numerous signaling cascades. Hence, targeting these dysregulated pathways would there- fore be an effective strategy to overcome cancer pathogenesis. Recently, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated nuclease 9 (Cas9) has emerged as an important technology to edit genes which are critical for several disease progression. Numerous studies have presented the importance of CRISPR-Cas9 in cancer diagnosis, generation of cancer models, cancer therapeutics, and epigenetic modification in oxidative stress-induced can- cer. This chapter will focus on the advantages and limitations of CRISPR-Cas9 as a therapeutics in oxidative stress-induced cancer.

Item Type:	Book Section
Uncontrolled Keywords:	Oxidative stress, Reactive oxygen species, Cancer, CRISPR-Cas9, Gene editing, Therapeutics
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology
Divisions:	Dept. of Biochemistry Protein Chemistry and Technology
Depositing User:	Somashekar K S
Date Deposited:	21 Nov 2025 09:04
Last Modified:	21 Nov 2025 09:04
URI:	http://ir.cftri.res.in/id/eprint/20111

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