Assessment of Clinical Profile and Treatment Outcome in Vaccinated and Unvaccinated SARS-CoV-2 Infected Patients

Ganesh, Korishettar and Prashanth, Chikkahonnaiah and SubbaRao, V Tulimilli and Siva, Dallavalasa and Shashidhar, H. Byrappa and SubbaRao, V. Madhunapantula and Ravindra, P. Veeranna (2022) Assessment of Clinical Profile and Treatment Outcome in Vaccinated and Unvaccinated SARS-CoV-2 Infected Patients. Vaccines, 10 (1125). pp. 1-14.

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Abstract

Vaccines against severe acute respiratory syndrome-corona virus-2 (SARS-CoV-2) infec- tion, which causes coronavirus disease–19 (COVID-19) in humans, have been developed and are being tested for safety and efficacy. We conducted the cross-sectional prospective cohort study on 820 patients who were positive for SARS-CoV-2 and were admitted to Princess Krishnajammanni trauma care centre (PKTCC), Mysore, which was converted to a designated COVID hospital between April 2021 to July 2021. After obtaining the informed consent, RT-PCR report, vaccination certificate and patient history, patients were classified according to their vaccination status. Results from the study showed decreases in serum ferritin levels, clinical symptoms, improvement in oxygen sat- uration, early recovery in patients having diabetes and hypertension, and a substantial reduction in the overall duration of hospital stay in vaccinated patients compared to unvaccinated patients. Further, fully vaccinated patients showed better outcomes compared to single dose vaccinated and nonvaccinated patients. Taken together, our findings reaffirm the vaccine’s effectiveness in reducing case fatality and promoting faster recovery compared to nonvaccinated patients. Efforts to increase the number of immunized subjects in the community help to achieve herd immunity and offer protection against the severity of COVID-19 and associated complications while minimizing the public health and economic burden.

Item Type:	Article
Uncontrolled Keywords:	SARS-CoV-2; COVID-19; vaccinated; nonvaccinated; cross-sectional prospective cohort study
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 11 Antibiotics Chemistry
Divisions:	Dept. of Biochemistry
Depositing User:	Somashekar K S
Date Deposited:	18 Dec 2025 11:07
Last Modified:	18 Dec 2025 11:07
URI:	http://ir.cftri.res.in/id/eprint/20224

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