Eugenol--an inhibitor of lipoxygenase-dependent lipid peroxidation.

Naidu, K. A. (1995) Eugenol--an inhibitor of lipoxygenase-dependent lipid peroxidation. Prostaglandins, Leukotrienes, and Essential Fatty Acids, 53 (5). pp. 381-3. ISSN 0952-3278

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Abstract

The effect of eugenol on enzymatic lipid peroxidation catalyzed by soybean lipoxygenase was studied in an in vitro system. Lipid peroxidation was inhibited by eugenol in a concentration-dependent manner. The half-maximal inhibition (IC50) was found to be 380 microM eugenol. Enzyme kinetic studies showed that eugenol non-competitively inhibited lipid peroxidation by altering the maximum velocity (Vmax) and without any change in Michaelis-Menten constant (Km) values. The inhibitory mechanism implies that eugenol does not inactivate the enzyme directly but may interfere with fatty acid radical intermediates due to its hydroxy radical scavenging ability and thus play a role in inhibiting the propagation of lipid peroxidation.

Item Type:	Article
Uncontrolled Keywords:	eugenol, lipid perioxidation
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 11 Lipid Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	26 Feb 2018 04:41
Last Modified:	26 Feb 2018 04:41
URI:	http://ir.cftri.res.in/id/eprint/2245

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