Interaction of Co, Mn, Mg and Al with d(GCGTACGC): a spectroscopic study.

Rajan, M. T. and Kumar, D. C. and Vishnuvardhan, D. and Rao, K. S. and Viswamitra, M. A. (1998) Interaction of Co, Mn, Mg and Al with d(GCGTACGC): a spectroscopic study. Molecular Biology Reports, 22 (1). pp. 47-52. ISSN 0301-4851

PDF Cellular and Molecular Life Sciences 1998 54(5) 488.pdf - Published Version Restricted to Registered users only Download (184kB)

Abstract

Spectroscopic study on the interactions of trace elements Co., Mn, Mg and Al with d(GCGTACGC) indicated the following: Al and Mg did not alter Tm values. Mn enhanced Tm at lower concentration and decreased it at higher concentrations. Interestingly Co at higher concentration elevated the Tm. These studies also showed lower concentrations of Mn displaced EtBr, whereas Al could displace it at higher ionic strength. Mg and Co displaced EtBr fluorescence at moderate concentrations. The binding constant values and CD spectra clearly indicated strong binding of these elements to DNA.

Item Type:	Article
Uncontrolled Keywords:	DNA; interactions; transitions; spectroscopy; trace elements
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	20 Feb 2012 06:25
Last Modified:	22 May 2012 10:32
URI:	http://ir.cftri.res.in/id/eprint/2261

Actions (login required)

View Item