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Antioxidant potential of bitter cumin (Centratherum anthelminticum (L.) Kuntze) seeds in in vitro models.
Ani, V. and Akhilender Naidu, K. (2011) Antioxidant potential of bitter cumin (Centratherum anthelminticum (L.) Kuntze) seeds in in vitro models. BMC Complementary and Alternative Medicine, 11. pp. 40-48.
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BMC Complementary and Alternative Medicine 2011, 11 40 (20 May 2011).pdf - Published Version Download (2MB) | Preview |
Abstract
Background: Bitter cumin (Centratherum anthelminticum (L.) Kuntze), is a medicinally important plant. Earlier, we have reported phenolic compounds, antioxidant, and anti-hyperglycemic, antimicrobial activity of bitter cumin. In this study we have further characterized the antioxidative activity of bitter cumin extracts in various in vitro models. Methods: Bitter cumin seeds were extracted with a combination of acetone, methanol and water. The antioxidant activity of bitter cumin extracts were characterized in various in vitro model systems such as DPPH radical, ABTS radical scavenging, reducing power, oxidation of liposomes and oxidative damage to DNA. Results: The phenolic extracts of bitter cumin at microgram concentration showed significant scavenging of DPPH and ABTS radicals, reduced phosphomolybdenum (Mo(VI) to Mo(V)), ferricyanide Fe(III) to Fe(II), inhibited liposomes oxidation and hydroxyl radical induced damage to prokaryotic genomic DNA. The results showed a direct correlation between phenolic acid content and antioxidant activity. Conclusion: Bitter cumin is a good source of natural antioxidants.
| Item Type: | Article |
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| Uncontrolled Keywords: | Bitter cumin Centratherum anthelminticum, polyphenolic compounds, antioxidants, DPPH, ABTS, reducing power, liposomes, oxidative DNA damage |
| Subjects: | 600 Technology > 08 Food technology > 30 Spices/Condiments 600 Technology > 08 Food technology > 32 Antioxidants |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 10 Feb 2012 04:28 |
| Last Modified: | 11 May 2012 03:22 |
| URI: | http://ir.cftri.res.in/id/eprint/10595 |
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