Enhancement in antimicrobial activity of 2-(phenyl)-3- (2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine

Sadashiva, M. P. and Mallesha, H. and Karunakara Murthy, K. and Rangappa, K. S. (2005) Enhancement in antimicrobial activity of 2-(phenyl)-3- (2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine. Bioorganic and Medicinal Chemistry Letters, 15. pp. 1811-1824.

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Abstract

The trans rich isomer, 2-(phenyl)-3-(2-butyl-4-chloro-1H-imidazolyl)-5-butylate isoxazolidine A (>96% ee) was synthesized by the condensation of E isomer rich nitrone 4 (>98% ee) with butyl acrylate in an inert solvent. Obtained isoxazolidine was screened for its antifungal activity against Aspergillus niger, Cephalosporium acremonium, Fusarium moniliforme by using Nystatin as positive control. It was also tested for its antibacterial activity against Bacillus subtilis, Escherichia coli, and Staphylococcus aureus by using Streptomycin as positive control. Enhanced antifungal activity was observed in isoxazolidine of >96% ee compared to the isoxazolidine of >69% ee (B), and enhancement was not observed in antibacterial activity.

Item Type:	Article
Uncontrolled Keywords:	Antifungal activity; Synthesis; Nitrone; Isoxazolidine
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 12 Microbial Biochemistry
Divisions:	Food Microbiology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	22 Jun 2007 11:01
Last Modified:	28 Dec 2011 09:28
URI:	http://ir.cftri.res.in/id/eprint/1255

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