Studies on co-administration of select gastrointestinal satiety peptides with obestatin to counter obesity.

ShreeRanga, Nagaraj (2017) Studies on co-administration of select gastrointestinal satiety peptides with obestatin to counter obesity. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Obestatin a 23 amino acid C-terminal amidated peptide was previously shown to reduce food intake, gain in body weight and triglyceride levels in the rodent model. To establish the mode of action of obestatin, mRNA profiling of the epididymal adipose tissue of mice treated with obestatin was performed. The differential expressions were markedly indicative of its involvement in lipid metabolism. Obestatin showed a significant upregulation of the genes patatin-like phospholipase domain containing 3,diacylglycerol O-acyltransferase 2, monoglyceride lipase, aldo–keto reductase family 1, member 7 which are involved in glycerolipid metabolism.

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	Obestatin obesity peptide
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 25 Peptide Chemistry
Divisions:	Protein Chemistry and Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	13 Jul 2017 08:45
Last Modified:	13 Jul 2017 08:45
URI:	http://ir.cftri.res.in/id/eprint/12820

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