Trace elements in Alzheimer's disease brain: A new hypothesis.

Jagannatha Rao, K. S. and Ranganath Rao, V. and Shanmugavelu, P. and Rani, B. Menon (1999) Trace elements in Alzheimer's disease brain: A new hypothesis. Alzheimer's Reports, 2 (4). pp. 211-216.

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Abstract

Trace elements AI, Fe, Zn, Cu, S, P, Mg, Si, Ca, Na, and K, were analysed in normal, moderately and severely affected Alzheimer's disease (AD) brains using Inductively Coupled Plasma Atomic Emission Spectrometer (ICPAES). In moderately affected brains, the monovalent elements Potassium and Phosphorus were significantly reduced, while divalent elements namely Calcium, Magnesium, Zinc and Copper were increased. In severely affected AD brains, Aluminium. Sulphur and Iron predominated. It was shown that Iron accumulates more in the brains of people with moderate and severe AD, while Aluminium deposition is greater in the severely affected AD brain. All the above results suggest that Iron deposits early in AD pathology while Aluminum deposits in the later phase of AD. These are the first findings to provide evidence of the distribution of trace elements and their inter-relationship with the severity of AD.

Item Type:	Article
Uncontrolled Keywords:	Trace elements, Alzheimer's disease
Subjects:	600 Technology > 01 Medical sciences > 02 Anatomy
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	14 Feb 2018 07:05
Last Modified:	14 Feb 2018 07:05
URI:	http://ir.cftri.res.in/id/eprint/13414

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