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Structural and functional characterization of new pigment molecule Monashin from Monascus purpureus CFR410-11.
Saikat, Mondal and Saritha, G. Pandit and Mohan Kumari, H. P. and Nanishankar, V. Harohally and Mohan, A. Dhale (2019) Structural and functional characterization of new pigment molecule Monashin from Monascus purpureus CFR410-11. Process Biochemistry, 82. pp. 173-178. ISSN 1359-5113
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Abstract
Biosynthetic pathway of Monascus pigment production is very complex. The mutant, M. purpureus CFR410-11 has produced new monacolin and subsequently it was predicted to produce new pigment molecule as well. Accordingly a pigment molecule was isolated by employing silica gel column chromatography. The TLC and HPLC data revealed the purity of isolated pigment molecule. The interpretation of UV-visible, NMR and HRMS spectra of the pigment lead to its identity as 10-Hydroxy-3-(Prop-1-en-1-yl)-5-undecanoyl-10,10a-1Hbenzo( g)isochromene-8-carbaldehyde and designated as monashin. Apparently, the production of new derivative of pigment molecule is due to the changes in biosynthetic pathway caused by the mutation or reduction, oxidation of other molecules. The pigment monashin exhibited the DPPH (26%), H2O2 (77%), and reducing power (0.57 AU) activity at 37.5, 40 and 46.15μg/ml concentration respectively. These antioxidant functions suggested the biological importance of monashin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Monascus purpureus CFR410-11; Mutant; Monashin; Pigment; Antioxidant |
| Subjects: | 600 Technology > 08 Food technology > 29 Microbiological food > 02 Fungi 600 Technology > 08 Food technology > 32 Antioxidants |
| Divisions: | Food Microbiology Plantation Products Spices and Flavour Technology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 22 Jul 2019 04:38 |
| Last Modified: | 22 Jul 2019 04:38 |
| URI: | http://ir.cftri.res.in/id/eprint/14205 |
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