Safety efficacy and chemical profiling of water-soluble Talaromyces purpureogenus CFRM02 pigment.

Saritha, G. Pandit and Mohan Kumari, H. P. and Muthukumar, S. P. and Mohan, A. Dhale (2020) Safety efficacy and chemical profiling of water-soluble Talaromyces purpureogenus CFRM02 pigment. Food Chemistry, 310. ISSN 0308-8146

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Abstract

Talaromyces purpureogenus CFRM02 pigments are non-toxic to Artemia franciscana. Further, in acute toxicity study, singledose(50,300,1000and2000mg/kgbodyweight)pigmentwas administeredtofemaleWistarrats. After 14days, no evidence of adverse effect on body weight, mortality and clinical signs were observed. Similarly, 28days sub-acute studies (250–1000mg/kg body weight) showed no significant changes in food intake, body weight gain and relative weight of vital organs. No signs of toxicity on biochemical, hematological parameters. Histopathological examination of the liver and kidney were normal. There were no marked changes in any of these rumen zymes activities.There were no significant changes in treated and control group(acuteand sub-acute). The HRMS data revealed the identification of purpuride, PP-O, PP-R, pentalsamonin, puractin-A, arginine-monascorubrin, purpurquinone-A, ankaflavin, purpactin-C. Theseresults confirmed safety efficacy of T. purpureogenus CFRM02 pigment and suggested applications in food and nutraceuticals.

Item Type:	Article
Uncontrolled Keywords:	Talaromyces purpureogenus; Toxicity; Pigment Chemical profiling HRMS
Subjects:	600 Technology > 01 Medical sciences > 17 Toxicology 600 Technology > 08 Food technology > 10 Food Microorganisms
Divisions:	Dept. of Biochemistry Fermentation Technology and Bioengineering Grain Science and Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	15 Jun 2020 05:41
Last Modified:	15 Jun 2020 05:41
URI:	http://ir.cftri.res.in/id/eprint/14385

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