Biodegradable chitosan-sodium alginate-oleic acid nanocarrier promotes bioavailability and target delivery of lutein in rat model with no toxicity.

Veeresh, T. and Naveen, J. and Muthukumar, S. P. and Baskaran, V. (2020) Biodegradable chitosan-sodium alginate-oleic acid nanocarrier promotes bioavailability and target delivery of lutein in rat model with no toxicity. Food Chemistry, 330. pp. 1-8. ISSN 0308-8146

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Abstract

Efficient delivery of macular carotenoid lutein to target retinal tissue is possible with enhanced intestinal uptake remains a major challenge owing to the polarity, sensitivity to light, heat and solubility. In this study, to overcome such constraints, biodegradable polymers chitosan-sodium alginate-oleic acid based nano-carrier loaded with lutein (LNCs) was prepared and safety efficacy was examined in vivo. Acute-toxicity of LNCs (0.1, 1, 10 and 100 mg/kg body weight) revealed that the LD50 of LNCs was higher than 100 mg/kg body weight. In subacute-toxicity of LNCs (1 and 10 mg/kg body weight) revealed no mortality with no morphological and clinical changes in rats. Histology, haematology and biochemical analysis of urine and plasma confirmed no toxicity of LNCs compared to control. Post-prandial plasma and tissue (retina) levels of lutein from LNCs were higher. Results demonstrate increased bioavailability of lutein from LNCs with no toxicity suggests applications in food and pharma.

Item Type:	Article
Uncontrolled Keywords:	Toxicity Lutein loaded nanocarrier system Natural polymers Bioavailability Drug delivery
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	30 Sep 2020 10:52
Last Modified:	30 Sep 2020 10:52
URI:	http://ir.cftri.res.in/id/eprint/14473

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