Cassia tora extract alleviates Ab1–42 aggregation processes in vitro and protects against aluminium-induced neurodegeneration in rats.

Sunil, K. Ravi and Ramesh, B. N. and Ravi, M. and Girish, T. K. and Vincent, B. (2020) Cassia tora extract alleviates Ab1–42 aggregation processes in vitro and protects against aluminium-induced neurodegeneration in rats. Journal of Pharmacy and Pharmacology, 72. pp. 1119-1132.

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Abstract

Objectives To examine the ability of Cassia tora extract to produce, in vitro and in vivo, beneficial effects with respect to events occurring during Alzheimer’s disease. Methods Previously characterised methanol extract of C. tora was tested for its ability to lessen Ab42 aggregation processes in vitro and to alleviate aluminiuminduced impairments in vivo in rats. Key findings Cassia tora extract prevents the aggregation of monomeric, oligomeric and fibrillary Ab1–42 in vitro. Moreover, the daily ingestion of 100 and 400 milligrams of the extract per kilogram of body weight for 60 days ameliorates the neurobehavioral and cognitive abilities of aluminium-treated rats in vivo. Importantly, treatments with the extract trigger a significant recovery of antioxidant enzymes function, a diminution of lipid peroxidation and acetylcholinesterase activity, a decrease of pro-inflammatory cytokines expression and an increase of brain-derived neurotrophic factor levels in both the hippocampus and the frontal cortex. Finally, we evidence that the extract is able to ameliorate the aluminiumdependent loss of neuronal integrity in the CA1 and CA3 regions of the hippocampus. Conclusions Altogether, our results reveal that methanol extract of C. tora is able to prevent typical AD-related events and therefore stands as a promising mild and natural anti-AD multitarget compound.

Item Type:	Article
Uncontrolled Keywords:	aluminium; Alzheimer’s disease; amyloid; Cassia tora; cognitive dysfunction; neuroprotection
Subjects:	500 Natural Sciences and Mathematics > 10 Plants
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	02 Dec 2020 11:31
Last Modified:	02 Dec 2020 11:31
URI:	http://ir.cftri.res.in/id/eprint/14673

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