Immune-boosting, antioxidant and anti-inflammatory food supplements targeting pathogenesis of COVID-19.

Pavithra, M. M. and Neelam, R. and Janhavi, P. and Prakash, M. Halami and Ravindra, P. V. (2020) Immune-boosting, antioxidant and anti-inflammatory food supplements targeting pathogenesis of COVID-19. Frontiers in Immunology.

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Abstract

The COVID-19 is an acute and contagious disease characterized by pneumonia and ARDS. The disease is caused by SARS-CoV-2, which belongs to the family of Coronaviridae along with MERS-CoV and SARS-CoV-1. The virus has the positive-sense RNA as its genome encoding for approximately 26 proteins that work together for the virus survival, replication, and spread in the host. The virus gets transmitted through the contact of aerosol droplets from infected persons. The pathogenesis of COVID18 19 is highly complex and involves suppression of host antiviral and innate immune response, induction of oxidative stress followed by hyper inflammation described as the "cytokine storm", causing the acute lung injury, tissue fibrosis, and pneumonia. Currently, several vaccines and drugs are being evaluated for their efficacy, safety, and for determination of doses for COVID-19 and this requires considerable time for their validation. Therefore, exploring the repurposing of natural compounds may provide alternatives against COVID24 19. Several nutraceuticals have a proven ability of immune-boosting, antiviral, antioxidant, anti25 inflammatory effects. These include Zn, vitamin D, vitamin C, curcumin, cinnamaldehyde, probiotics, selenium, lactoferrin, quercetin, etc. Grouping some of these phytonutrients in the right combination in the form of a food supplement may help to boost the immune system, prevent virus spread, preclude the disease progression to severe stage, and further suppress the hyper inflammation providing both prophylactic and therapeutic support against COVID-19.

Item Type:	Article
Uncontrolled Keywords:	SARS-CoV-2, COVID-19, Pathogenesis, Food supplements, Immune-boosting, Antioxidant, Anti-inflammation
Subjects:	600 Technology > 01 Medical sciences > 13 Nutrition-Human 600 Technology > 08 Food technology > 32 Antioxidants
Divisions:	Dept. of Biochemistry Food Microbiology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	31 Dec 2020 10:50
Last Modified:	31 Dec 2020 10:50
URI:	http://ir.cftri.res.in/id/eprint/14725

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