Zerumbone augments cognitive enhancement potentials of EPA+DHA: Insight from a hyperlipidemic rat model.

Vinayak, Uppin and Pooja, Acharya and Bettadaiah, B. K. and Ramaprasad, T. R. (2020) Zerumbone augments cognitive enhancement potentials of EPA+DHA: Insight from a hyperlipidemic rat model. The British Journal of Nutrition, 124 (12). pp. 1353-1360.

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Abstract

Hyperlipidemia and cognitive dysfunction (CD) are the two public health concerns. Though hyperlipidemia has been comprehensively studied in respect of cardiovascular diseases, its role on CD needs to be explored. Hence, we evaluated hyperlipidemia as a risk factor for CD, and the efficacy of eicosapentaenoic acid (EPA, 20:5n-3) + docosahexaenoic acid (DHA, 22:6n-3), and zerumbone (Z) in modulating CD under hyperlipidemic conditions. Male Wistar rats (Rattus norvegicus) were fed control, high-fat (HF), high-fat + fish oil (HF+F), high-fat + zerumbone (HF+Z), and high-fat + fish oil + zerumbone (HF+F+Z) containing diet. After 30 days feeding trial, memory parameters [(Morris water maze, elevated plus maze (transfer latency), and T-maze (spontaneous alteration)], and locomotor skills (open field test and rotarod test) were assessed. Hyperlipidemia significantly (p<0.05) reduced memory and motor coordination skills compared to control. However, the administration of EPA+DHA and zerumbone significantly (p<0.05) restored the hyperlipidemia-induced loss of memory and motor coordination skills. Collectively, our data imply that hyperlipidemia causes CD by decreasing the memory and motor coordination skills, and administration of EPA+DHA and zerumbone prevent hyperlipidemia induced CD. The augmented effect of EPA+DHA, together with zerumbone, discloses a promising strategy for lowering the severity of CD in hyperlipidemic conditions.

Item Type:	Article
Uncontrolled Keywords:	Memory deficits: Locomotion impairment: Eicosapentaenoic acid: Docosahexaenoic acid: Hyperlipidemia: Zerumbone
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 11 Lipid Biochemistry 600 Technology > 01 Medical sciences > 13 Nutrition-Human 600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions:	Dept. of Biochemistry Plantation Products Spices and Flavour Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	07 Jan 2021 09:47
Last Modified:	07 Jan 2021 09:47
URI:	http://ir.cftri.res.in/id/eprint/14771

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