![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
High cholesterol-supplemented diet during gestation and lactation alters liver glycosaminoglycans and associated lipoprotein receptors and results in fat accumulation in adulthood.
Sanjana, J. and Nandini, C. D. (2021) High cholesterol-supplemented diet during gestation and lactation alters liver glycosaminoglycans and associated lipoprotein receptors and results in fat accumulation in adulthood. Nutrition Research, 93. pp. 50-60.
![[img]](http://ir.cftri.res.in/style/images/fileicons/other.png) |
PDF
Nutrition Research 93 (2021) 50–60.pdf - Published Version Restricted to Registered users only Download (2MB) | Request a copy |
Abstract
In utero insults to growing fetus impact its health in adulthood. Glycosaminoglycans (GAGs) are involved in lipoprotein metabolism in the liver and vary both quantitively and qualitatively on feeding adult rats a diet rich in cholesterol. However, no reports are available to show the modulation of GAGs when the offspring are subjected to a high cholesterol diet in gestation and lactation stages. Hypercholesterolemia in pregnant rats was induced by feeding an AIN-93 diet supplemented with 0.5% cholesterol. The pups born to mothers fed with high cholesterol diet showed a significant increase in cholesterol and triglycerides accumu- lation in the liver. Quantitative changes in sulfated glycosaminoglycans (sGAGs), in particular of heparan sulfate, were observed across the developmental stages. Other players involved in lipoprotein metabolism, namely low-density lipoprotein receptor-related protein 1, apolipoprotein E, and low-density lipoprotein receptor expression levels, also showed differential changes across developmental stages. Interestingly, when pups from hypercholes- terolemic mothers were fed a normal diet after weaning until adulthood, a considerable amount of fat accumulation in the liver was observed, implicating fetal exposure to early high cholesterol exposure on long term health.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Maternal nutrition Sulfated glycosaminoglycans Associated lipoprotein receptors High cholesterol diet Metabolic diseases |
| Subjects: | 600 Technology > 01 Medical sciences > 13 Nutrition-Human |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 29 Nov 2021 04:42 |
| Last Modified: | 29 Nov 2021 04:42 |
| URI: | http://ir.cftri.res.in/id/eprint/15101 |
Actions (login required)
 |
View Item |