Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes.

Basista Rabina, Sharma and Swarna, Jaiswal and Ravindra, P. V. (2022) Modulation of gut microbiota by bioactive compounds for prevention and management of type 2 diabetes. Biomedicine & Pharmacotherapy, 152. p. 113148.

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Abstract

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by hyperglycemia and insulin resistance. Gut microbiota (GM) are specific groups of microbes colonized in the gastrointestinal (GI) tract. They profoundly influence health, disease protection, and associated with metabolic activities, and play a vital role in the production of functional metabolites from dietary substances. Dysbiosis of GM has been linked to the onset of T2DM and can be altered to attain eubiosis by intervention with various nutritional bioactive compounds such as polyphenols, prebiotics, and probiotics. This review presents an overview of the evidence and underlying mechanisms by which bioactive compounds modulate the GM for the prevention and management of T2DM.

Item Type:	Article
Uncontrolled Keywords:	Type 2 diabetes Gut microbiota Eubiosis Dysbiosis
Subjects:	600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	13 Sep 2022 08:27
Last Modified:	13 Sep 2022 08:27
URI:	http://ir.cftri.res.in/id/eprint/15736

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