Efficient L-Proline catalyzed synthesis of some new (4-substituted-phenyl)-1,5-dihydro-2H-pyrimido[4,5- d][1,3]thiazolo[3,2a]-pyrimidine-2,4(3H)-diones bearing thiazolopyrimidine derivatives and evaluation of their pharmacological activities.

Sukanya, S.H. and Venkatesh, T. and Aditya Rao, S. J. and Muthipeedika Nibin, Joy (2022) Efficient L-Proline catalyzed synthesis of some new (4-substituted-phenyl)-1,5-dihydro-2H-pyrimido[4,5- d][1,3]thiazolo[3,2a]-pyrimidine-2,4(3H)-diones bearing thiazolopyrimidine derivatives and evaluation of their pharmacological activities. Journal of Molecular Structure, 1247. p. 131324.

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Abstract

In the present study, a simple and efficient protocol has been developed to synthesize a se�ries of new (4-substituted-phenyl)-1,5-dihydro-2H-pyrimido[4,5-d][1,3]thiazolo[3,2a]-pyrimidine-2,4(3H)- dione derivatives (4a-g) through L-proline-catalyzed reaction of 2-amino-4-(4-substituted-phenyl)thiazole (1), substituted benzaldehyde (2), and barbituric/thiobarbituric acid (3) at a refluxed temperature in aque�ous ethanol under mild and metal-free conditions. The obtained compounds were evaluated for in vitro cytotoxicity and anti-inflammatory effects. The in silico docking studies provided the probable interactions of synthesized compounds with P38 MAP kinase and MMP-9 proteins. The structures of all the synthe�sized compounds were confirmed using analytical and spectroscopic techniques. The in vitro cytotoxic�ity studies revealed the potential cytotoxic effects of the compounds 4f and 4g. The anti-inflammatory studies suggested the prominent anti-inflammatory effects of the compounds 4a and 4g. The SAR stud�ies showed the importance of electron-withdrawing groups in enhancing the potency among the tested compounds. The results of in silico studies supported our findings from in vitro analysis in terms of drug�likeness of the synthesized compounds and their effective interactions with P38 MAP kinase and MMP-9 proteins envisaging their use as prominent therapeutic agents

Item Type:	Article
Uncontrolled Keywords:	Thaizole-pyrimidine derivatives Cytotoxicity Anti-inflammatory SAR ADME-toxicology study Molecular docking
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 02 Amino Acid Biochemistry
Divisions:	Plant Cell Biotechnology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	13 Sep 2022 11:13
Last Modified:	13 Sep 2022 11:13
URI:	http://ir.cftri.res.in/id/eprint/15750

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