Hyperphagia in ofsprings of in utero hyperglycemic mothers is associated with increased expression of heparan sulfate proteoglycans in hypothalamus.

Sandeep, S. and Chandra, G. and Nandini, C. D. (2022) Hyperphagia in ofsprings of in utero hyperglycemic mothers is associated with increased expression of heparan sulfate proteoglycans in hypothalamus. Molecular and Cellular Biochemistry, 477. pp. 2025-2032. ISSN 0300-8177

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Abstract

In utero hyperglycemia has consequences on future outcomes in the ofsprings. We had earlier shown that in utero hypergly�cemia impacts proteoglycans/glycosaminoglycans, one of the key molecules involved in brain development. Hypothalamic HSPGs such as syndecan-1 and syndecan-3 are well known for their involvement in feeding behavior. Therefore, studies were carried out to determine the efect of maternal hyperglycemia on the expression of HSPGs in the hypothalamus of ofspring brain. Results revealed increased protein abundance of Syndecan-1 and -3 as well as glypican-1 in postnatal adults from hyperglycemic mothers. This was associated with increased hyperphagia and increased expression of Neuropeptide Y. These results indicate the likely consequences on ofsprings exposed to in utero hyperglycemia on its growth.

Item Type:	Article
Uncontrolled Keywords:	In utero hyperglycemia · Heparan sulfate proteoglycans · Sulfated glycosaminoglycans · Hypothalamus · Feeding behavior
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 16 Protein Biochemistry
Divisions:	Molecular Nutrition
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	25 Jan 2023 06:17
Last Modified:	25 Jan 2023 06:17
URI:	http://ir.cftri.res.in/id/eprint/15881

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