Combinatorial epigenetic approach against triple-negative breast cancer.

Dhanamjai, Penta (2022) Combinatorial epigenetic approach against triple-negative breast cancer. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Triple-negative breast cancer (TNBC) is the most aggressive type of breast cancer with poor clinical outcomes. There is no specific targeted therapy available for TNBC patients. Hence, they undergo standard chemotherapy and encounter early chemoresistance as well as tumor relapse. Hence, there is a pertinent therapeutic strategy indispensable to facilitating the clinical outcome of TNBC patients. More recently, combination therapy with bioactive phytochemicals is getting wider attention not only due to the reduction in the drug-associated toxicity but also the synergism found with available therapeutics. In the current study, 3, 3’-diindolylmethane (DIM), a dietary bioactive rich in cruciferous vegetables, has been studied for the synergistic effect with centchroman (CC), a female oral contraceptive that has been effective against breast cancer. The results have shown that DIM and CC synergistically inhibited cell proliferation and induced apoptosis in breast cancer cells.

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	Triple-negative breast cancer, combination therapy, bioactive phytochemicals, cruciferous vegetables, centchroman
Subjects:	600 Technology > 01 Medical sciences 600 Technology > 08 Food technology > 23 Vegetables
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	18 May 2023 10:26
Last Modified:	18 May 2023 10:26
URI:	http://ir.cftri.res.in/id/eprint/16409

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