COVID-19: Diabetes Perspective—Pathophysiology and Management.

Siva, Dallavalasa and SubbaRao, V. Tulimilli and Janhavi, Prakash and Ramya, Ramachandra and SubbaRao, V. Madhunapantula and Ravindra, P. V. (2023) COVID-19: Diabetes Perspective—Pathophysiology and Management. Pathogens, 12. p. 184.

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Abstract

Recent evidence relating to the impact of COVID-19 on people with diabetes is limited but continues to emerge. COVID-19 pneumonia is a newly identified illness spreading rapidly throughout the world and causes many disabilities and fatal deaths. Over the ensuing 2 years, the indirect effects of the pandemic on healthcare delivery have become prominent, along with the lingering effects of the virus on those directly infected. Diabetes is a commonly identified risk factor that contributes not only to the severity and mortality of COVID-19 patients, but also to the associated complications, including acute respiratory distress syndrome (ARDS) and multi-organ failure. Diabetic patients are highly affected due to increased viral entry into the cells and decreased immunity. Several hypotheses to explain the increased incidence and severity of COVID-19 infection in people with diabetes have been proposed and explained in detail recently. On the other hand, 20–50% of COVID-19 patients reported new-onset hyperglycemia without diabetes and new-onset diabetes, suggesting the two-way interactions between COVID-19 and diabetes. A systematic review is required to confirm diabetes as a complication in those patients diagnosed with COVID-19. Diabetes and diabetes-related complications in COVID-19 patients are primarily due to the acute illness caused during the SARS-CoV-2 infection followed by the release of glucocorticoids, catecholamines, and pro-inflammatory cytokines, which have been shown to drive hyperglycemia positively. This review provides brief insights into the potential mechanisms linking COVID-19 and diabetes, and presents clinical management recommendations for better handling of the disease.

Item Type:	Article
Uncontrolled Keywords:	COVID-19; SARS-CoV-2; diabetes; glucocorticoids; cytokines; ARDS
Subjects:	600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	08 Dec 2023 08:31
Last Modified:	08 Dec 2023 08:31
URI:	http://ir.cftri.res.in/id/eprint/16832

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