Coffee leaf extract exhibits anti‑obesity property and improves lipid metabolism in high‑fat diet‑induced C57BL6 obese mice.

Siddhi, Patil and Moumita, Das and Suresh Kumar, G. and Pushpa, S. Murthy (2023) Coffee leaf extract exhibits anti‑obesity property and improves lipid metabolism in high‑fat diet‑induced C57BL6 obese mice. 3 Biotech, 13. p. 278.

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Abstract

In the present study, the effect of coffee leaf extract (CLE) on in vitro enzyme inhibition was studied. Furthermore, its impact on the high-fat diet (HFD)-induced obese mice (C57BL/6) at the levels of 100 and 200 mg/kg body weight along with positive control (orlistat) and the normal group maintained with starch-fed diet (SFD) was observed. CLE had significant α amylase and lipase enzyme inhibitory properties. In HFD-induced obese mice, treatment with CLE significantly reduced the body weight gain. The investigation demonstrated that CLE administration lowered blood glucose, total cholesterol, total triglycerides and LDL levels while increasing the HDL levels. It reduced the development of fatty liver by reducing hepatic fat accumulation and decreased the fat cell size in the adipose tissue. Further, CLE significantly increased the liver antioxidant enzyme activities and lowered the levels of hepatotoxicity markers in the serum when compared to the HFDfed mice. The treatment also downregulated the mRNA expression of lipogenic transcription factors (SREBP-1c, CEBP-α) and enzymes (ACC, FAS) than HFD. Overall, the results indicate that coffee leaves have anti-obesity potential and can be used as functional ingredients in the development of innovative products for managing lifestyle disorders such as obesity.

Item Type:	Article
Uncontrolled Keywords:	Coffee leaves · Histopathology · Lipogenic genes · Obesity · Serum lipid profile
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 11 Lipid Biochemistry 600 Technology > 01 Medical sciences > 12 Metabolism 600 Technology > 07 Beverage Technology > 04 Coffee
Divisions:	Dept. of Biochemistry Plantation Products Spices and Flavour Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	09 Dec 2023 06:09
Last Modified:	09 Dec 2023 06:09
URI:	http://ir.cftri.res.in/id/eprint/16872

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