Effect of cyclodextrin-complexed lyophilized nanosuspension of Nigella sativa seeds oleoresin on chronic unpredictable mild stress (CUMS)-induced depression in mice

Kaustav, Nag and Deepak, Solanki and Muthukumar, S. P. and Seema, Mehdi and Rajan, Logesh and Tamsheel Fatima, Roohi and Nabeel, Kinattingal and Faiyaz, Shakeel (2024) Effect of cyclodextrin-complexed lyophilized nanosuspension of Nigella sativa seeds oleoresin on chronic unpredictable mild stress (CUMS)-induced depression in mice. Neuroscience Letters, 834. pp. 1-7.

PDF 1-s2.0-S0304394024002222-main.pdf - Published Version Restricted to Registered users only Download (1MB) | Request a copy

Abstract

Depression is a prevalent global health concern necessitating alternative approaches to conventional antide­ pressant medications due to its associated adverse effects. Nigella sativa (NS) is recognized for its potential as an antidepressant, offering a promising solution with fewer side effects. This study investigated the antidepressant efficacy of cyclodextrin-complexed lyophilized nanosuspension of NS oleoresin (NSOR) in a murine model of chronic unpredictable mild stress (CUMS)-induced depression. This study sought to evaluate and contrast the antidepressant potential of the nano-NSOR with that of the NS ethanolic extract (NSEE). The prepared nano-NSOR was characterized physicochemically and evaluated for in vitro drug release and in vivo antidepressant activity. The particle size of nano-NSOR was determined to be 164.6 nm. In vitro drug release studies suggested the higher drug release from nano-NSOR (90.15 % after 72 h) compared to the native NSOR (59.55 % after 72 h). Furthermore, nano-NSOR exhibited a more pronounced antidepressant effect than NSEE in the context of CUMS-induced depression. This study highlights a potential alternative for managing depression, addressing the need for improved antidepressant treatments with reduced side effects. These results suggest that nano-NSOR ame­ liorates CUMS-induced depression by modulating neurotransmitter levels, reducing inflammation, and enhancing neuroprotection.

Item Type:	Article
Uncontrolled Keywords:	Chronic unpredictable mild stress, Depression, Lyophilized nanosuspension, Nigella sativa, Oleoresin
Subjects:	500 Natural Sciences and Mathematics > 10 Plants 500 Natural Sciences and Mathematics > 11 Animals
Divisions:	Dept. of Biochemistry
Depositing User:	Somashekar K S
Date Deposited:	05 Mar 2025 10:35
Last Modified:	05 Mar 2025 10:35
URI:	http://ir.cftri.res.in/id/eprint/19185

Actions (login required)

View Item