Effect of long term feeding and withdrawal of aflatoxin B1 and ochratoxin A on kidney cell transformation in albino rats.

Rati, E. R. and Shantha, T. and Ramesh, H. P. (1991) Effect of long term feeding and withdrawal of aflatoxin B1 and ochratoxin A on kidney cell transformation in albino rats. Indian Journal of Experimental Biology, 29 (9). pp. 813-7. ISSN 0019-5189

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Abstract

Subacute doses (1/20 LD50) of aflatoxin B1 and ochratoxin A were fed to weanling albino rats individually and in combination for 36 weeks and then rats were maintained on toxin free normal diet for a period of 24 weeks. Livers of rats were fatty, wherever aflatoxin was administered but the enzyme activity did not show significant differences among various groups. However, in a few individuals whose livers were severely affected, higher concentrations of urine creatinine, liver RNA and DNA, and ALT enzyme activity were recorded. Histopathological examination showed various stages of hepatoma and hepatocarcinoma including nodular hyperplasia, hypertrophy, vacuolisation, degeneration, pseudolobulation, cellular infiltration and fibrosis of liver of rats fed with aflatoxin individually and in combination. Few anaplastic cells in the corticomedullary region and nuclear enlargement of proximal tubular epithelium of kidney were found wherever combined toxin and ochratoxin alone were administered. Liver tumor expression was time dependent.

Item Type:	Article
Uncontrolled Keywords:	aflatoxin b1, ochratoxin A, kidney cell transformation
Subjects:	500 Natural Sciences and Mathematics > 08 Botanical sciences > 01 Botany > 03 Fungi 600 Technology > 01 Medical sciences > 17 Toxicology
Divisions:	Food Microbiology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	15 Nov 2021 04:59
Last Modified:	15 Nov 2021 04:59
URI:	http://ir.cftri.res.in/id/eprint/2326

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