Effect of curcumin and capsaicin on the regression of pre-established cholesterol gallstones in mice.

Hussain, M. S. and Chandrasekhara, N. (1994) Effect of curcumin and capsaicin on the regression of pre-established cholesterol gallstones in mice. Nutrition Research, 14 (10). pp. 1561-1574.

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Abstract

The efficacy of curcumin and capsaicin in causing regression of pre-established cholesterol gallstones (CGS) was investigated in male mice. After confirming the formation of CGS in 100% of the mice, they were fed on a diet containing 0.5% curcumin or 5 mg% capsaicin for 5 or 10 weeks. 5 weeks feeding of curcumin or capsaicin diet caused a regression of CGS in 45 and 64% of the mice, respectively. 10 weeks feeding caused regression of CGS in 80% of the mice. Biliary cholesterol decreased and phospholipids and bile acids increased with increase in the duration of spice feeding. Feeding of a control diet to the mice bearing CGS neither caused regression of CGS nor influenced biliary lipids significantly.

Item Type:	Article
Uncontrolled Keywords:	spices-; medicinal-plants; cholesterol-metabolism; biliary-calculi; regression-; curcumin-; capsaicin-; intake-; amides-; phenolic-compounds; pharmacology-; digestive-system
Subjects:	600 Technology > 08 Food technology > 30 Spices/Condiments 600 Technology > 01 Medical sciences > 05 Dietetics
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	15 Jun 2011 07:17
Last Modified:	28 Dec 2011 10:03
URI:	http://ir.cftri.res.in/id/eprint/8427

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