Microencapsulation of Lutein and its Bioavailability for Macular Pigment Deficiency Disorder

Shrikalaa, K. (2010) Microencapsulation of Lutein and its Bioavailability for Macular Pigment Deficiency Disorder. [Student Project Report]

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Abstract

This Dissertation / Report is the outcome of investigation carried out by the creator(s) / author(s) at the department/division of Central Food Technological Research Institute (CFTRI), Mysore mentioned below in this page.

Item Type:	Student Project Report
Additional Information:	Age Related Macular Degeneration (AMD) is a physiological condition caused by the degeneration of the central region of retina called macula in the elderly population (age >60). This condition leads to loss of central vision that is responsible for acuity. Worldwide AMD is regarded as the third major reason for causing blindness. There are large number of risk factors associated with this condition: age, obesity, lack of physical exercise, sunlight exposure etc. Age is one major risk factor leading to AMD. Due to aging humans begin to lose the efficiency with which we absorb the retinal carotenoids: lutein and zeaxanthin. These pigments acts in two ways in maintaining the normal physiology of the eyes. Firstly, they acts as filters of blue light that filters the harmful blue light in generating oxidizing complexes that can cause potential damage to retinal cells. Secondly, these carotenoids function as antioxidants thus preventing for superoxide radicals. Besides these some chemical drugs are available to treat/prevent AMD from progressing. It is now evident that the carotenoid supplementation in diet is an interesting alternative for treatment. The formulation of these carotenoids in the form of tablets has certain disadvantages. The tablets are difficult to swallow by the elderly. Since lutein is photolabile and heatlabile, the dosage in the form of tablet supplemented may not be the actual dosage at the time of consumption. This project aims at the development of microencapsulated lutein by the spray drying technique. Also the bioavailablity of lutein from the encapsulated product is analysed for scaling the technique to industrial scale. By encapsulating lutein, it is prevented from the light induced damage or oxidative damage. Further the product being easily reconstitutable leads to increased absorption and hence an increase in the bioavailable lutein. Therefore microencapsulation of lutein is an interesting alternative for lutein supplementation in AMD patients. The product was found to be free flowing and pale yellow in color. The structure of microencapsulated product was examined by scanning electron microscopy. Its physical, organoleptic, biochemical and nutritional qualities were evaluated. From the results it is concluded that the product can be delivered successfully from natural sources using microencapsulation by spray drying technique.
Uncontrolled Keywords:	Age Related Macular Degeneration; AMD; carotenoid supplementation; microencapsulated lutein; spray drying
Subjects:	600 Technology > 01 Medical sciences > 13 Nutrition-Human
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	07 Jul 2010 06:45
Last Modified:	28 Dec 2011 10:14
URI:	http://ir.cftri.res.in/id/eprint/9456

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