Studies on the Role of Dietary Galectin- Inhibitor on Galectin and Galectin Binding Protein Mediated Metastasis.

Sindhuja, H. N. (2016) Studies on the Role of Dietary Galectin- Inhibitor on Galectin and Galectin Binding Protein Mediated Metastasis. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Metastasis is a crucial step in cancer pathogenicity and adds severity to the disease mainly because of the entry of cancer cell into a highly manipulative stage. Several studies including studies from our laboratory have indicated that galectin-3 plays a key role in metastasis. Galectin-3 binding protein (G3BP) is reported as a ligand for galectin-3. G3BP is a heavily Nglycosylated protein with a molecular mass of 90 kDa and it appears to mediate cell-cell adhesion via bridging galectin-3 molecules on adjacent tumor cells in a carbohydrate-dependent manner.

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	galectin-3 G3BP mediated metastasis
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 16 Protein Biochemistry
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	13 Jul 2017 08:58
Last Modified:	13 Jul 2017 08:58
URI:	http://ir.cftri.res.in/id/eprint/12821

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