Recent insights into the molecular regulators and mechanisms of taurine to modulate lipid metabolism: a review.

Lipid metabolism disorders such as hypertriglyceridemia and hypercholesterolemia are risk factors
for cardiovascular diseases and atherosclerosis that are grave public health issues. Taurine, a
sulfur-containing non-essential amino acid exerts a wide range of physiological effects that regulate
lipid metabolic disorders. Although the effects of taurine on lipid-lowering have been reported in
animals and humans, mechanisms elucidating the lipid-lowering action of taurine remain unclear.
A series of molecular regulators associated with lipid metabolism have been identified in the past
few decades. These include nuclear receptors, transcription factors, and enzymes that undergo
important changes during taurine treatment. In this review, we focus on the role of taurine in
lipid metabolism and discuss taurine-related interventions in combating lipid disorders.