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Bacteriocins future perspectives: Substitutes to antibiotics
Athira, Cheruvari and Rajagopal, Kammara (2025) Bacteriocins future perspectives: Substitutes to antibiotics. Food Control, 168. pp. 1-18.
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Abstract
Background: Antimicrobials are substances that either eradicate or inhibit the growth of microorganisms. The days of traditional antibiotics are over since their overuse has led to worldwide health and environmental issues. Thus, there is a need for novel antimicrobial proteins/peptides with improved properties over existing ones. The goal of microbiology research over the past ten years has been to identify, create, and market antimicrobials from benign microorganisms that are just as effective. The bioactive peptides or proteins, synthesized by probiotics and other beneficial microorganisms, are also referred to as postbiotics. The application of the recently created postbiotics is unrestricted in the food sector. Nisin and pediocin are two postbiotics that are widely used in the worldwide food sector. If successful, they could also be the best candidates to be therapeutic proteins that take the place of traditional antibiotics. Scope and approach: To gain a comprehensive understanding of today’s postbiotic landscape, it’s crucial to grasp the importance of bacteriocin and its diverse applications across various sectors such as food, heterologous expression, bioprocessing, and as a substitute for antibiotics. Key findings and conclusions: Peptides with antibacterial properties that are authorized for use in the food industry are known as bacteriocins. They are utilized in agriculture, the food industry, and other fields. Due to new re strictions, stronger antiviral treatments are among the novel antimicrobial drugs being researched. The potential application of bacteriocins in COVID-19 therapy is under investigation. Additionally, other alternatives such as plant-based chemicals, animal venoms, and bacteriophage therapy have also contributed to the development of antibiotic substitutes.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Postbiotics, Probiotics, Lactococcus, Nisin, Pediocin, Antimicrobials |
| Subjects: | 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 11 Antibiotics Chemistry |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Somashekar K S |
| Date Deposited: | 25 Feb 2025 04:42 |
| Last Modified: | 25 Feb 2025 04:42 |
| URI: | http://ir.cftri.res.in/id/eprint/19146 |
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