Progress and promises of epigenetic drugs and epigenetic diets in cancer prevention and therapy: A clinical update

Priya, Mondal and Jagadish, Natesh and Dhanamjai, Penta and Syed Musthapa, Meeran (2022) Progress and promises of epigenetic drugs and epigenetic diets in cancer prevention and therapy: A clinical update. Seminars in Cancer Biology, 83. pp. 503-522.

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Abstract

Epigenetic modifications are heritable yet reversible, essential for normal physiological functions and biological development. Aberrant epigenetic modifications, including DNA methylation, histone modification, and non- coding RNA (ncRNA)-mediated gene regulation play a crucial role in cancer progression. In cellular reprogramming, irregular epigenomic modulations alter cell signaling pathways and the expression of tumor suppressor genes and oncogenes, resulting in cancer growth and metastasis. Therefore, alteration of epigenetic-status in cancer cells can be used as a potential target for cancer therapy. Several synthetic epigenetic inhibitors (epi-drugs) and natural epigenetic modulatory bioactives (epi-diets) have been shown to have the potential to alter the aberrant epigenetic status and inhibit cancer progression. Further, the use of combinatorial approaches with epigenetic drugs and diets has brought promising outcomes in cancer prevention and therapy. In this article, we have summarized the epigenetic modulatory activities of epi-drugs, epi-diets, and their combination against various cancers. We have also compiled the preclinical and clinical status of these epigenetic modulators in different cancers.

Item Type:	Article
Uncontrolled Keywords:	Cancer epigenetics, Epigenetic drugs, Epigenetic diets, Dietary bioactives, Clinical trials
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology
Divisions:	Dept. of Biochemistry
Depositing User:	Somashekar K S
Date Deposited:	05 Mar 2025 09:45
Last Modified:	05 Mar 2025 09:45
URI:	http://ir.cftri.res.in/id/eprint/19167

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