Circulatory levels of lysophosphatidylcholine species in obese adolescents: Findings from cross-sectional and prospective lipidomics analyses

Sapna, Sharma and Yalamanchili Venkata, Subrahmanyam and Harish, Ranjani and Sidra, Sidra and Dharmeshkumar, Parmar and Sangeetha, Vadivel and Shanthini, Kannan and Harald, Grallert and Dandamudi, Usharani and Ranjit Mohan, Anjana and Muthuswamy, Balasubramanyam and Viswanathan, Mohan and Adamski, Jerzy and Venkateswarlu, Panchagnula and Kuppan, Gokulakrishnan (2024) Circulatory levels of lysophosphatidylcholine species in obese adolescents: Findings from cross-sectional and prospective lipidomics analyses. Nutrition, Metabolism & Cardiovascular Diseases (34). pp. 1807-1816.

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Abstract

Background and aims: Obesity has reached epidemic proportions, emphasizing the importance of reliable biomarkers for detecting early metabolic alterations and enabling early preventative interventions. However, our understanding of the molecular mechanisms and spe- cific lipid species associated with childhood obesity remains limited. Therefore, the aim of this study was to investigate plasma lipidomic signatures as potential biomarkers for adolescent obesity. Methods and results: A total of 103 individuals comprising overweight/obese (n Z 46) and normal weight (n Z 57) were randomly chosen from the baseline ORANGE (Obesity Reduction and Noncommunicable Disease Awareness through Group Education) cohort, having been followed up for a median of 7.1 years. Plasma lipidomic profiling was performed using the UHPLC-HRMS method. We used three different models adjusted for clinical covariates to analyze the data. Clustering methods were used to define metabotypes, which allowed for the stratification of subjects into subgroups with similar clinical and metabolic profiles. We observed that ly- sophosphatidylcholine (LPC) species like LPC.16.0, LPC.18.3, LPC.18.1, and LPC.20.3 were significantly (p < 0.05) associated with baseline and follow-up BMI in adolescent obesity. The association of LPC species with BMI remained consistently significant even after adjusting for po- tential confounders. Moreover, applying metabotyping using hierarchical clustering provided in-sights into the metabolic heterogeneity within the normal and obese groups, distinguishing metabolically healthy individuals from those with unhealthy metabolic profiles. Conclusion: The specific LPC levels were found to be altered and increased in childhood obesity, particularly during the follow-up. These findings suggest that LPC species hold promise as potential biomarkers of obesity in adolescents, including healthy and unhealthy metabolic profiles. ª 2024 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	Lysophosphatidyl-choline; Adolescent obesity; Biomarker; Lipidomics; Asian Indians
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 06 Cellular Biochemistry
Divisions:	Food Safety Analytical Quality Control Lab
Depositing User:	Somashekar K S
Date Deposited:	06 Mar 2025 05:21
Last Modified:	06 Mar 2025 05:21
URI:	http://ir.cftri.res.in/id/eprint/19199

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