Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study.

Chandrappa, S. and Vinaya, K. and Srikanta, B. M. and Ananda Kumar, C. S. (2009) Novel N-Substituted Thiazolidinones as Proton Pump Inhibitors and Potent Anti-Ulcer Agents: SAR Study. Letters in Drug Design & Discovery , 6 (2).

Full text not available from this repository.

Abstract

A series of N-substituted thiazolidinone derivatives 5(a-j) was synthesized in good yield. All the compounds were screened for their in vitro H+, K+- ATPase inhibitory activity. The structures of the synthesized compounds were confirmed by the spectral data. Compounds 5d, 5e, 5f and 5c showed potential H+, K+- ATPase blocking activities, when compared to standard drug Lansoprazole. Structure-activity relationship studies, with various chemical groups, revealed that position and nature of the substitution on the N-thiazolidinones are crucial for H+, K+- ATPase inhibitory activity.

Item Type:	Article
Uncontrolled Keywords:	Anti-Ulcer Agents; thiazolidinone derivatives
Subjects:	600 Technology > 01 Medical sciences > 15 Pharmacology 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 24 Organic Chemistry
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	09 Aug 2011 07:03
Last Modified:	09 Aug 2011 07:03
URI:	http://ir.cftri.res.in/id/eprint/10436

Actions (login required)

View Item