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Potentiation of the hypolipidemic influence of dietary tender cluster bean (Cyamopsis tetragonoloba) by garlic in cholesterol fed rats.

Shubhra, Pande and Srinivasan, Krishnapura (2012) Potentiation of the hypolipidemic influence of dietary tender cluster bean (Cyamopsis tetragonoloba) by garlic in cholesterol fed rats. Food Chemistry, 133. pp. 798-805. ISSN 0308-8146

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Abstract

Tender cluster bean (Cyamopsis tetragonoloba) (CB), a rich source of soluble fibre was evaluated for hypolipidemic influence in atherogenic situation along with a known hypocholesterolemic spice garlic in rats. Wistar rats were rendered hypercholesterolemic by feeding 0.5% cholesterol diet for 8 weeks. Inclusion of CB (15%), garlic (1%) and their combination in high-cholesterol diet produced significant hypolipidemic effects. The combination produced 56% decrease in serum cholesterol. Decrease in serum cholesterol seen in basal groups by these dietary interventions was additive with the combination. Increase in serum triglycerides was countered in animals fed CB, garlic or their combination. Elevation in hepatic cholesterol and triglycerides was countered by CB and garlic, the combination reducing it even more. Biliary secretion of bile acids was increased by CB, garlic and their combination in atherogenic condition. Thus, garlic potentiated the beneficial influence of dietary CB on serum, liver and biliary lipids in high-cholesterol fed situation.

Item Type: Article
Uncontrolled Keywords: Cluster beans, Garlic, Hypocholesterolemic effect Lipid profile
Subjects: 600 Technology > 08 Food technology > 22 Legumes-Pulses
600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions: Dept. of Biochemistry
Depositing User: Food Sci. & Technol. Information Services
Date Deposited: 23 Apr 2012 07:00
Last Modified: 03 Jul 2015 07:19
URI: http://ir.cftri.res.in/id/eprint/10674

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