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Decaleside: a new class of natural insecticide targeting tarsal gustatory sites.
Rajashekar, Y. and Jagan Mohan Rao, L. and Shivanandappa, T. (2012) Decaleside: a new class of natural insecticide targeting tarsal gustatory sites. Naturwissenschaften, 99. pp. 843-852.
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Abstract
Natural sources for novel insecticide molecules hold promise in view of their eco-friendly nature, selectivity, and mammalian safety. Recent progress in understanding the biology of insect olfaction and taste offers new strategies for developing selective pest control agents.We have isolated two natural insecticidal molecules from edible roots of Decalepis hamiltonii named Decalesides I and II, which are novel trisaccharides, highly toxic to household insect pests and storedproduct insects. We have experimentally shown that insecticidal activity requires contact with tarsi on the legs but is not toxic orally. The insecticidal activity of molecules is lost by hydrolysis, and various sugars modify toxic response, showing that the insecticidal activity is via gustatory sites on the tarsi. Selective toxicity to insects by virtue of their gustatory site of action and the mammalian safety of the new insecticides is inherent in their chemical structure with 1-4 or 1-1 α linkage that is easily hydrolyzed by digestive enzymes of mammals. Decalesides represent a new chemical class of natural insecticides with a unique mode of action targeting tarsal chemosensory/gustatory system of insects.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Natural insecticides . Decalesides I and II . Trisaccharides . Tarsi . Gustatory receptors . Digestive enzymes |
| Subjects: | 600 Technology > 03 Agriculture > 05 Insect/Pest Control |
| Divisions: | Food Protectants and Infestation Control Plantation Products Spices and Flavour Technology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 15 Nov 2012 11:06 |
| Last Modified: | 15 Nov 2012 11:06 |
| URI: | http://ir.cftri.res.in/id/eprint/11009 |
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