Curcumin-glucoside, A Novel Synthetic Derivative of Curcumin, Inhibits alpha-Synuclein Oligomer Formation: Relevance to Parkinson’s Disease.

Bharathi, S. G. and Parvathy, K. S. and Srinivas, P. and Indi, S. S. and Rao, K. S. (2012) Curcumin-glucoside, A Novel Synthetic Derivative of Curcumin, Inhibits alpha-Synuclein Oligomer Formation: Relevance to Parkinson’s Disease. Current Pharmaceutical Design, 18. pp. 76-84.

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Abstract

alpha-Synuclein aggregation is centrally implicated in Parkinson’s disease (PD). It involves multi-step nucleated polymerization process via the formation of dimers, soluble toxic oligomers and insoluble fibrils. In the present study, we synthesized a novel compound viz., Curcumin-glucoside (Curc-gluc), a modified form of curcumin and studied its anti-aggregating potential with alpha-synuclein. Under aggregating conditions in vitro, Curc-gluc prevents oligomer formation as well as inhibits fibril formation indicating favorable stoichiometry for inhibition. The binding efficacies of Curc-gluc to both

Item Type:	Article
Uncontrolled Keywords:	Alpha-synuclein, Parkinson’s disease, curcumin-glucoside, oligomer, aggregation
Subjects:	600 Technology > 01 Medical sciences 600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions:	Dept. of Biochemistry Plantation Products Spices and Flavour Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	11 Mar 2013 05:48
Last Modified:	11 Mar 2013 05:48
URI:	http://ir.cftri.res.in/id/eprint/11140

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