Antibacterial and antimutagenic activities of novel zerumbone analogues.

Santosh Kumar, S. C. and Srinivas, P. and Negi, P. S. and Bettadaiah, B. K. (2013) Antibacterial and antimutagenic activities of novel zerumbone analogues. Food Chemistry, 141. pp. 1097-1103. ISSN 0308-8146

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Abstract

Zerumbone, the key constituent of Zingiber zerumbet Smith, is a very important bioactive phytochemical. Two new compounds viz. azazerumbone 1 and azazerumbone 2 were synthesised by ZnCl2-catalysed Beckmann rearrangement of the zerumbone oxime. The structure elucidation of these analogues of zerumbone was carried out by 1D (1H NMR and 13C NMR) and 2D-NMR (COSY, HSQC and NOESY) spectral analysis. Studies on the antibacterial activity established that azazerumbone 2 had better activity than zerumbone. Among the tested bacteria, Bacillus cereus was the most sensitive and Yersinia enterocolitica was found to be the most resistant. These compounds exhibited strong protection against sodium azide induced mutagenicity of Salmonella typhimurium strains TA 98 and TA 1531. Azazerumbone 2 showed better antibacterial and antimutagenic activity than azazerumbone 1. The antibacterial and antimutagenic activities exhibited by zerumbone and its analogues demonstrate their potential for use as nutraceuticals and in food preservation.

Item Type:	Article
Uncontrolled Keywords:	Zerumbone Zerumbone oxime Azazerumbone Azazerumbone Zerumbol Antibacterial action Antimutagenic activity
Subjects:	600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions:	Fruit and Vegetable Technology Plantation Products Spices and Flavour Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	11 Jun 2013 04:07
Last Modified:	01 Jul 2015 12:58
URI:	http://ir.cftri.res.in/id/eprint/11221

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