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Biochemical and physiological responses in Caenorhabditis elegans exposed to sublethal concentrations of the organophosphorus insecticide, monocrotophos.
Leelaja, B. C. and Rajini, P. S. (2013) Biochemical and physiological responses in Caenorhabditis elegans exposed to sublethal concentrations of the organophosphorus insecticide, monocrotophos. Ecotoxicology and Environmental Safety, 94. pp. 8-13.
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Ecotoxicology and Environmental Safety, Volume-94( (2013) 8-13.pdf - Published Version Restricted to Registered users only Download (674kB) |
Abstract
The objective of this study was to investigate the impact of sublethal concentrations of MCP on definitive markers of toxicity and oxidative balance in the nematode, Caenorhabditis elegans. Exposure of worms to 0.85, 1.7 and 3.4 mM (1/40, 1/20 and 1/10 LC50; LC50=34 mM) for 4 h at 20 °C induced significant perturbations in physiological parameters such as decreased brood size (47–73%), increased paralysis (47–85%) and inhibition of the activities of acetylcholinesterase (75–86%) and carboxylesterase (76–81%). These changes were accompanied by distinct oxidative impairments as evidenced by increased reactive oxygen species, decline in glutathione content and decrease in superoxide dismutase activity. Our results clearly demonstrate that low concentrations of MCP may alter the physiological and biochemical status in the nematode, thereby affecting the organism's fitness. Our findings on C. elegans provide an easy diagnosis for OPI contamination and may become helpful in evaluating the ecotoxicological effects of OPI in the aquatic environment near agricultural fields.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Monocrotophos; Acetylcholinesterase; Carboxylesterase; Oxidative stress; Caenorhabditis elegans |
| Subjects: | 600 Technology > 01 Medical sciences > 17 Toxicology |
| Divisions: | Food Protectants and Infestation Control |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 20 Mar 2015 10:24 |
| Last Modified: | 20 Mar 2015 10:24 |
| URI: | http://ir.cftri.res.in/id/eprint/11234 |
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