Lymphatic Transport of a-Linolenic Acid and Its Conversion to Long Chain n-3 Fatty Acids in Rats Fed Microemulsions of Linseed Oil.

Sugasini, D. and Devaraj, V. C. and Ramesh, M. and Lokesh, B. R. (2014) Lymphatic Transport of a-Linolenic Acid and Its Conversion to Long Chain n-3 Fatty Acids in Rats Fed Microemulsions of Linseed Oil. Lipids, 49 (3). pp. 225-233.

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Abstract

In the present study we evaluated the uptake of ALA and its conversion to EPA ? DHA in rats given linseed oil (LSO) in native form or as a microemulsion in whey protein or in lipoid. In a single oral dose study in which rats maintained on rodent pellets deficient in x-3 fatty acids were intubated with 0.35 g LSO in lipoid, the amount of ALA present in lymph was increased reaching a maximum concentration of 16.23 mg/ml at 2.5 h. The amount of ALA present in lymph was increased to a maximum level of 10.95 mg/ml at 4 h in rats given LSO as a microemulsion in whey protein. When LSO was given without emulsification, the amount of ALA present in lymph was found to reach a maximum level of 7.08 mg/ml at 6 h. A similar result was observed when weaning rats were intubated with 0.15 g of LSO per day for a period of 60 days. Higher levels of ALA by 41 and 103 % were observed in lymph lipids of rats given microemulsions of LSO in whey protein and in lipoid respectively as compared to rats given LSO without pre-emulsification. Very little conversion of ALA to EPA and DHA was observed in lymph lipids but higher amounts of EPA ? DHA was observed in liver and serum of rats given LSO in microemulsion form. This study indicated that ALA concentration in lymph lipids was increased when LSO was given in microemulsion form in lipoid and further conversion to EPA and DHA was facilitated in liver and serum.

Item Type:	Article
Uncontrolled Keywords:	n-3 Fatty acids nutrition Edible oils nutrition Fat absorption physiology Lipid absorption physiology Docosahexaenoic acid specific lipids Fatty acids specific lipids n-3 Fatty acids specific lipids
Subjects:	600 Technology > 08 Food technology > 19 Lipids-oils/fats > 01 Oilseeds
Divisions:	Lipid Science and Traditional Foods
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	28 May 2014 05:34
Last Modified:	28 May 2014 05:34
URI:	http://ir.cftri.res.in/id/eprint/11582

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