Studies on the influence of CCK-8 on the ability of obestatin to reduce food intake, gain in body weight and related lipid parameters

In an effort to mimic in part the redundancy of satiety peptides involved in energy homeostasis, the
combined benefits of the well-established satiety peptide CCK8 and an apparently anorectic peptide
obestatin were studied in Swiss albino mice. The optimal dose of obestatin that was required to give the
most pronounced effect with CCK8 was worked out by varying the concentration of obestatin while
keeping CCK8 concentration constant at 200 nmol/KgBW. Mice administered 160 nmol obestatin and
200 nmol CCK8 per kilogram body weight showed the most drastic reduction in food intake. Gain in
body weight was arrested after day four during the eight day experiment. These studies reemphasize the
beneficial effects imparted by co-administration of obestatin and CCK8 and their potential use towards
countering obesity.