Synthesis, antibacterial and antimutagenic activity of zerumbonebicarbonyl analogues

Santosh Kumar, S. C. and Negi, P. S. and Manjunatha, J. R. and Bettadaiah, B. K. (2017) Synthesis, antibacterial and antimutagenic activity of zerumbonebicarbonyl analogues. Food Chemistry, 221. pp. 576-581.

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Abstract

Synthesis of new zerumbone-bicarbonyl analogues by SeO2 oxidation is reported. Selective oxidation of methyl at C-13 to an aldehyde and a ketone with exo-cyclic double bond between C-13 and C-6 in zerumbone has been recognized. Both these compounds have an additional conjugated-carbonyl-functionality. They exhibited significantly higher antimutagenic activity than zerumbone against Salmonella tester strains. They are more active against Gram positive bacteria than Gram negative bacteria; however zerumbone showed highest activity against E. coli, whereas its derivatives were least effective against E. coli.

Item Type:	Article
Uncontrolled Keywords:	Selenium dioxide Zerumbal Zerumbenone Antibacterial activity Anti-mutagenic activity
Subjects:	600 Technology > 08 Food technology > 30 Spices/Condiments
Divisions:	Fruit and Vegetable Technology Plantation Products Spices and Flavour Technology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	28 Dec 2016 10:23
Last Modified:	28 Dec 2016 10:23
URI:	http://ir.cftri.res.in/id/eprint/12599

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