Targeting Wnt Signaling in Endometrial Cancer.

Iram, Fatima and Susmita, Barman and Rajani, Rai (2021) Targeting Wnt Signaling in Endometrial Cancer. Cancers, 13. p. 2351.

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Abstract

This review presents new findings on Wnt signaling in endometrial carcinoma and implications for possible future treatments. The Wnt proteins are essential mediators in cell signaling during vertebrate embryo development. Recent biochemical and genetic studies have provided significant insight into Wnt signaling, in particular in cell cycle regulation, inflammation, and cancer. The role of Wnt signaling is well established in gastrointestinal and breast cancers, but its function in gynecologic cancers, especially in endometrial cancers, has not been well elucidated. Development of a subset of endometrial carcinomas has been attributed to activation of the APC/�-catenin signaling pathway (due to �-catenin mutations) and downregulation of Wnt antagonists by epigenetic silencing. The Wnt pathway also appears to be linked to estrogen and progesterone, and new findings implicate it in mTOR and Hedgehog signaling. Therapeutic interference of Wnt signaling remains a significant challenge. Herein, we discuss the Wnt-activating mechanisms in endometrial cancer and review the current advances and challenges in drug discovery.

Item Type:	Article
Uncontrolled Keywords:	Wnt signaling endometrial carcinoma
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 16 Protein Biochemistry 600 Technology > 01 Medical sciences
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	21 Feb 2022 04:11
Last Modified:	21 Feb 2022 04:11
URI:	http://ir.cftri.res.in/id/eprint/15122

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