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Polysaccharide from Spirulina platensis Evokes Antitumor Activity in Gastric Cancer Cells via Modulation of Galectin‑3 and Exhibited Cyto/DNA Protection: Structure−Function Study.
Vinayak, Uppin and Shylaja, M. Dharmesh and Sarada, R. (2022) Polysaccharide from Spirulina platensis Evokes Antitumor Activity in Gastric Cancer Cells via Modulation of Galectin‑3 and Exhibited Cyto/DNA Protection: Structure−Function Study. Journal of Agricultural and Food Chemistry, 70. pp. 7058-7069. ISSN 0021-8561
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Abstract
Polysaccharides play significant role in the management of different cancer types including gastric cancer. Here, we report the effect of spirulina polysaccharide (Sp) on galectin-3 modulatory activity in gastric cancer cells (AGS). The isolated Sp possessed an average molecular weight of 1457 kDa and galactose (42%) as a major sugar consisting of (β1−4D) units with a galactoarabinorhamnoglycan backbone. The Sp inhibited the proliferation of AGS cells by 48% without affecting normal NIH/3T3 cells as compared to doxorubicin, a known anticancer drug. Also, Sp exhibited significant (p < 0.05) galectin-3 mediated hemeagglutination inhibition with MIC of 9.37 μg/mL compared to galactose (6.25 μg/mL), a sugar specific to galectin-3. Galactose showed the highest molecular interaction with galectin-3 in the in silico study. In addition, Sp exhibited the cytoprotection in RBCs, buccal cells, and DNA exposed to oxidants. These findings suggest that Sp offers a promising therapeutic tool in the management of gastric cancer
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cytoprotection, galectin-3, gastric cancer, metastasis, spirulina polysaccharide |
| Subjects: | 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 28 Polysaccharide Chemistry 500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology > 01 Algae |
| Divisions: | Dept. of Biochemistry Plant Cell Biotechnology |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 24 Jan 2023 09:09 |
| Last Modified: | 24 Jan 2023 09:09 |
| URI: | http://ir.cftri.res.in/id/eprint/15849 |
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