Development of lutein nanocarrier and evaluation of its effect on retinal angiogenesis in the hyperglycaemic animal model.

Veeresh, Toragall (2022) Development of lutein nanocarrier and evaluation of its effect on retinal angiogenesis in the hyperglycaemic animal model. Doctoral thesis, Central Food Technological Research Institute.

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Abstract

Diabetic retinopathy (DR) is a frequent microvascular complication of diabetes and a major cause of vision loss globally. DR ranked as the fifth most common cause of preventable blindness and the fifth most common cause of moderate to severe visual impairment. The low bioavailability of the drugs at the target site imposed by the anatomic and physiologic barriers within the eye requires long-term treatments with frequent injections that often compromise patient’s compliance and increase the risk of developing more complications. In recent years, much effort has been put towards developing new drug delivery platforms aiming to enhance their permeation, prolong their retention time at the target site and provide a sustained release profile with reduced toxicity and improved efficacy. Hence, the present study aimed to enhance lutein bioavailability and bioefficacy by encapsulating it in a hybrid polymer-lipid-based nanocarrier system. It is hypothesized that the “Lutein loaded nanocarrier system enhances the solubility, stability bioavailability and bioefficacy of lutein and also helps in slow and controlled release of lutein at the target site to modulate oxidative stress and inflammation in delaying or preventing retinal angiogenesis through the restoration of angiogenic markers in STZ induced diabetic rat”.

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	Diabetic retinopathy, lutein bioavailability, bioefficacy, encapsulation, hybrid polymer-lipid-based nanocarrier system
Subjects:	500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 14 Carotenoid Chemistry 600 Technology > 01 Medical sciences > 04 Diabetes Mellitus
Divisions:	Dept. of Biochemistry
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	19 May 2023 09:04
Last Modified:	19 May 2023 09:04
URI:	http://ir.cftri.res.in/id/eprint/16423

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