Identification and Evaluation of Acyltransferase Inhibitors from Edible Plant Sources for Management and Prevention of Obesity.

Yeshvanthi, Singh (2022) Identification and Evaluation of Acyltransferase Inhibitors from Edible Plant Sources for Management and Prevention of Obesity. Doctoral thesis, Central Food Technological Research Institute.

PDF Yeshvanthi Singh.pdf - Submitted Version Restricted to Repository staff only Download (7MB)

Abstract

Currently obesity has become a major health problem and the discovery of highly efficacious and well tolerated lipid lowering drugs has become the major focus of scientific research. Though many studies have provided solutions that can control diet-induced obesity, these solutions impart various complications and side effects upon long term usage. Hence, there isa need for safer alternatives that modulate the enzymes that are involved in obesity. The dietary triacylglycerol (TAG) gets absorbed and accumulated in the body through the monoacylglycerol (MAG) pathway, which plays a major role in obesity and related disorders. The main enzyme of this pathway, monoacylglycerol acyltransferase 2 (MGAT2) is considered as a potential target for developing anti-obesity compounds. Food based natural molecules that modulate MGAT2 in the small intestine can be developed as safe and effective nutraceuticals for obesity and other related complications. There is a need for in vitro cell- based assays for screening the potential natural leads for MGAT2 inhibition. Therefore; we optimized a 2-MAG induced TAG accumulation inhibitory cell-based assay to screen natural extracts using the HIEC-6 cell line

Item Type:	Thesis (Doctoral)
Uncontrolled Keywords:	obesity, Food based natural molecules, nutraceuticals, plant based, hydro- ethanolic and aqueous extracts.
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 03 Biochemistry & Molecular Biology > 07 Enzyme Biochemistry 600 Technology > 01 Medical sciences > 13 Nutrition-Human 600 Technology > 08 Food technology > 20 Plant Food
Divisions:	Dept. of Lipid Science
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	19 May 2023 09:43
Last Modified:	19 May 2023 09:43
URI:	http://ir.cftri.res.in/id/eprint/16425

Actions (login required)

View Item