Amyloid-β-Derived Peptidomimetics Inhibits Tau Aggregation.

Nalini, Vijay Gorantla and Lisni, P. Sunny and Rajasekhar, K. and Pramod, G. Nagaraju and Poornima Priyadarshini, C. G. (2021) Amyloid-β-Derived Peptidomimetics Inhibits Tau Aggregation. ACS Omega, 6. pp. 11131-11138.

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Abstract

The aggregation of tau protein is one of the hallmarks for Alzheimer’s disease, resulting in neurodegeneration. The peptidomimetics strategy to prevent tau aggregation is more specific over other small molecules. In the present study, we analyzed the effect of amyloid-β-derived peptidomimetics for inhibiting heparin-induced tau aggregation in vitro. These peptides and their derivatives were known to prevent aggregation of amyloid-β. KLVFF is a hydrophobic sequence of the pentapeptide that prevented tau aggregation as observed by thioflavin S fluorescence, transmission electron micros�copy, and circular dichroism spectroscopy. P4 and P5 also prevented assembly of tau into aggregates and formed short fibrils. The β-sheet breaker LPFFD was however ineffective in preventing tau aggregation. The peptides further demonstrated reversal of tau-induced cytotoxicity in a dose-dependent manner. Our results suggested that these peptides can also be used to inhibit tau aggregation and also, toxicity induced by tau could be considered as potential molecules that have an effect on tau as well as amyloid-β

Item Type:	Article
Uncontrolled Keywords:	tau protein, amyloid-β, s potential molecules
Subjects:	600 Technology > 08 Food technology > 16 Nutritive value > 03 Proteins
Divisions:	Molecular Nutrition
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	19 May 2023 11:05
Last Modified:	19 May 2023 11:05
URI:	http://ir.cftri.res.in/id/eprint/16428

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