Partially saturated canthaxanthin purified from Aspergillus carbonarius induces apoptosis in prostrate cancer cell line.

Kumaresan, N. and Sanjay, K. R. and Venkatesh, S. K. and Ravi Kumar, Kadeppagari and Vijayalakshmi, G. and Umesh Kumar, S. (2008) Partially saturated canthaxanthin purified from Aspergillus carbonarius induces apoptosis in prostrate cancer cell line. Applied Microbiology and Biotechnology, 80. pp. 467-473. ISSN 0175-7598

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Abstract

A mutant Aspergillus carbonarius selected for temperature tolerance after UV treatment, when grown in shake flasks, produced mycelia bearing yellow pigment. Since the mutant was affected in sterol biosynthetic pathway, the pigment was apparently produced to maintain membrane fluidity and rigidity for growth sustenance in low-pH culture broth. Nuclear magnetic resonance analyses characterizing the pigment as a partially saturated canthaxanthin, containing beta-ionone end rings, suggested its application as a retinoid. When tested for this property in retinoic acid receptor expressing prostate cancer cell line, LNCaP, the fungal partially saturated canthaxanthin induced apoptosis. Low apoptosis percentage in DU145 prostrate cancer cells that does not express functional retinoic acid receptor-beta (RAR-beta) suggested binding specificity of the partially saturated canthaxanthin for RAR-beta.

Item Type:	Article
Uncontrolled Keywords:	Aspergillus carbonarius . Partially saturated canthaxanthin . Apoptosis . LNCaP. DU145 . HeLa . Retinoic acid receptors
Subjects:	500 Natural Sciences and Mathematics > 07 Life Sciences > 04 Microbiology
Divisions:	Food Microbiology
Depositing User:	Food Sci. & Technol. Information Services
Date Deposited:	02 Jan 2009 09:08
Last Modified:	23 May 2012 07:07
URI:	http://ir.cftri.res.in/id/eprint/1779

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