![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Prebiotic and Antiproliferation Effects of Arabinogalactan Isolated from Green Gram (Vigna radiata) and Its Hydrolysates.
Kiranmayi, Ketha and Muralikrishna, G. (2024) Prebiotic and Antiproliferation Effects of Arabinogalactan Isolated from Green Gram (Vigna radiata) and Its Hydrolysates. Annals of Agricultural & Crop Sciences, 9 (4). pp. 1-7.
|
Text
aacs-v9-id1160.pdf Download (1MB) | Preview |
Abstract
Special Article: Legumes Prebiotic and Antiproliferation Effects of Arabinogalactan Isolated from Green Gram (Vigna radiata) and Its Hydrolysates Kiranmayi Ketha; Muralikrishna Gudipati* Department of Biochemistry, CSIR- Central Food Technological Research Institute, Mysuru, Karnataka, India *Corresponding author: G Muralikrishna FAFST (I), FACCT(I) MNASc, Formerly Chief Scientist (Scientist-G) & Formerly HOD, Professor AcSIR, Depart- ment of Biochemistry, CSIR-Central Food Technological Research Institute, Mysuru 570020, Karnataka, India. Tel: +91-821-2516531 (R) Mobile (0) +91-9480382199 Email: krishnagm2002@yahoo.com Received: May 30, 2024 Accepted: June 25, 2024 Published: July 02, 2024 Annals of Agricultural & Crop Sciences Volume 9, Issue 4 (2024) www.austinpublishinggroup.com Gudipati M © All rights are reserved Citation: Ketha K, Gudipati M. Prebiotic and Antiproliferation Effects of Arabinogalactan Isolated from Green Gram (Vigna radiata) and Its Hydrolysates. Ann Agric Crop Sci. 2024; 9(4): 1160. Annals of Agricultural & Crop Sciences Open Access Abstract An Arabinogalactan (AGP) derived from green gram and its hy- drolysates (AGO, Arabinogalacto oligosaccharides) were screened for their prebiotic potential and antiproliferation effects on co- lon cancer cells (in vitro). Three lactobacilli strains namely L. aci- dophilus, L. delbrucki and L. fermentum showed relatively better response towards AGP and AGO as compared with other tested strains with respect to defined prebiotic characteristics. The ac- tivities of α-L-arabinofuranosidase (39 to 89.5 mU/mL) and β-D- galactopyranosidase (19 to 49.5 mU/mL) in the culture broth in- dicated the breakdown of AGP and AGO into constituent sugars and their subsequent utilization for the growth of bacteria. AGP and AGO exhibited dose dependent cytotoxic and anti-proliferative effects on (p <0.001) Caco-2 cells with IC50 values of 150 and 500 μg/mL, respectively as estimated by MTT assay. The present study demonstrated the prebiotic properties of AGP and AGO as well as their ability to provide natural defence against colon cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Arabinogalactan; green gram; prebiotic activity; anti- proliferation; Caco- 2 cell line |
| Subjects: | 500 Natural Sciences and Mathematics > 04 Chemistry and Allied Sciences > 13 Carbohydrate Chemistry 600 Technology > 08 Food technology > 22 Legumes-Pulses |
| Divisions: | Dept. of Biochemistry |
| Depositing User: | Food Sci. & Technol. Information Services |
| Date Deposited: | 15 Oct 2024 11:11 |
| Last Modified: | 15 Oct 2024 11:11 |
| URI: | http://ir.cftri.res.in/id/eprint/18227 |
Actions (login required)
 |
View Item |